Single-Cell and Functional Genomics

Single-cell genomics and genome-wide functional screens serve as core technologies for modern systems biology. Multi-modal single-cell analysis has transformed our ability to interrogate biological processes and gene regulation, even in complex tissues. Combining these powerful observational tools with CRISPR-based functional perturbations could lead to computational models that can predict cellular behavior. This course will explore the foundational principles underlying these experimental technologies, discuss their applications in basic and translational research, and introduce computational approaches for gleaning biological insight from high-dimensional genomic data.