Principles of Genomic Technol

Lect: 3. Chemical and physical aspects of genome structure and organization, genetic information flow from DNA to RNA to Protein. Nucleic acid hybridization and sequence complexity of DNA and RNA. Genome mapping and sequencing methods. The engineering of DNA polymerase for DNA sequencing and polymerase chain reaction. Fluorescent DNA sequencing and high-throughput DNA sequencer development. Construction of gene chip and micro array for gene expression analysis. Technology and biochemical approach for functional genomics analysis. Gene discovery and genetics database search method. The application of genetic database for new therapeutics discovery