Adv Eukaryotc Moleculr Genetcs

Required for second year Genetics and Development students. Open to all students. Prerequisite: at least one graduate-level biochemistry or molecular biology course, and instructor’s permission. Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problem sets on the current literature.